A novel secreted cyclophilin-like protein (SCYLP)

Novel Secreted , Ameloblast - specific Protein − −

Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells.

Th cell subsets, namely Th1 and Th2 cells, play an important role in mounting an immune response against invading pathogens. Several genes are selectively up-regulated during differentiation and effector phases of Th subsets. In this study, we report the identification of a novel cytokine-like molecule designated FISP (IL-4-induced secreted protein), which is selectively expressed and secreted ...

Cyclophilin Inhibitors as a Novel HCV Therapy

A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence. CyPA probably interacts directly with nonstructural protein 5A to exert its effect, through its peptidyl-prolyl isomerase activity, on maintaining the proper structure and function of the HCV replicase. The major proline substrates are located ...

Secreted Protein Acidic and Rich in Cysteines-Like 1 Suppresses

Secreted Protein Acidic and Rich in Cysteines-Like 1 Suppresses 1 Aggressiveness and Predicts Better Survival in Colorectal Cancers 2 Hanguang Hu, Hang Zhang, Weiting Ge, Xiyong Liu, Sofia Loera, Peiguo Chu, Huarong 3 Chen, Jiaping Peng, Lun Zhou, Shujing Yu, Ying Yuan, Suzhan Zhang, Lily Lai, Yun 4 Yen, Shu Zheng 5 1 Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China...

Secreted calmodulin-like skin protein ameliorates scopolamine-induced memory impairment.

Humanin, a short bioactive peptide, inhibits cell death in a variety of cell-based death models through Humanin receptors in vitro. In vivo, Humanin ameliorates both muscarinic receptor antagonist-induced memory impairment in normal mice and memory impairment in Alzheimer's disease (AD)-relevant mouse models including aged transgenic mice expressing a familial AD-linked gene. Recently, calmodul...